OpGen Subsidiary Ares Genetics GmbH Enters into Collaboration Agreement with the Belgian National Reference Centre for Invasive S. pneumoniae at UZ Leuven
- Collaborators aim to develop and evaluate computation tools, including predictive models for whole genome sequencing-based antibiotic susceptibility testing (wgsAST)
- Ares plans to strategically expand its proprietary AMR knowledgebase ARESdb with data collected during the collaboration
- Ares to deploy the commercial AREScloud web application at UZ Leuven to support pathogen typing, AMR characterization and outbreak analysis
AMR is a serious threat to public health. Over five years, the estimated number of annual deaths that might have been prevented by effective antimicrobial therapy has grown by 81% to approximately 1.27 million deaths.1,2 Among other AMR pathogens, the
Ares Genetics and UZ Leuven aim to employ machine learning tools for antibiotic susceptibility testing of Streptococcus pneumoniae directly from whole genome sequencing data. The AI-based wgsAST technology developed by Ares Genetics4 relies on predictive models which are trained on ARESdb, a proprietary AMR knowledgebase and collection of pathogen genome data and associated data on phenotypic antibiotic susceptibility and resistance.
“We are excited to jointly demonstrate and advance the utility of antibiotic susceptibility prediction directly from genome data. AMR in respiratory pathogens, including in Pneumococci, is a serious healthcare threat,” said Dr.
The collaboration with UZ Leuven follows after another collaboration agreement between Ares Genetics and an unnamed international commercial reference laboratory had been announced in 2021.
Ares Genetics plans to expand ARESdb with data collected at the national reference center, to develop and deploy wgsAST models for Streptococcus pneumoniae, and to jointly evaluate their performance compared to conventional methods. In return for access to genome and AMR phenotype data, Ares Genetics will deploy AREScloud at the
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This press release includes statements regarding OpGen’s subsidiary Ares Genetics GmbH’s collaboration agreement with the Belgian National Reference Center at UZ Leuven. These statements and other statements regarding OpGen’s future plans and goals constitute "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934 and are intended to qualify for the safe harbor from liability established by the Private Securities Litigation Reform Act of 1995. Such statements are subject to risks and uncertainties that are often difficult to predict, are beyond our control, and which may cause results to differ materially from expectations. Factors that could cause our results to differ materially from those described include, but are not limited to, the success of our commercialization efforts, our ability to successfully, timely and cost-effectively develop, seek and obtain regulatory clearance for and commercialize our product and services offerings, the rate of adoption of our products and services by hospitals and other healthcare providers, the fact that we may not effectively use proceeds from recent financings, the continued realization of expected benefits of our business combination transaction with
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