OpGen, Inc.

708 Quince Orchard Road, Suite 205

Gaithersburg, MD 20878



February 6, 2020


United States Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549
Attention: Tim Buchmiller


Re:OpGen, Inc.
Registration Statement on Form S-3
File Number 333-236106


Ladies and Gentlemen:


On behalf of OpGen, Inc., (the “Company”), and pursuant to Rule 461 under the Securities Act of 1933, as amended, the undersigned respectfully requests that the effective date for the above-referenced Registration Statement on Form S-3, as amended, be accelerated so that it will be declared effective at 4:00 p.m. on February 7, 2020, or as soon thereafter as is practicable.

Please direct any questions regarding the foregoing to the undersigned at (301) 869-9683 or to Peter Jaslow at (215) 864-8737.




/s/ Timothy C. Dec                

Timothy C. Dec

Chief Financial Officer
OpGen, Inc.



cc: Peter Jaslow, Esq.