March 6, 2019

Evan Jones
Chief Executive Officer
OPGEN INC
708 Quince Orchard Road, Suite 205
Gaithersburg, MD 20878

       Re: OPGEN INC
           Registration Statement on Form S-1
           Filed March 1, 2019
           File No. 333-230036

Dear Mr. Jones:

       This is to advise you that we have not reviewed and will not review your
registration
statement.

        Please refer to Rules 460 and 461 regarding requests for acceleration.
We remind you
that the company and its management are responsible for the accuracy and
adequacy of their
disclosures, notwithstanding any review, comments, action or absence of action
by the staff.

       Please contact David Link at (202) 551-3356 with any questions.



                                                            Sincerely,

                                                            Division of
Corporation Finance
                                                            Office of
Beverages, Apparel and
                                                            Mining
cc:    Mary Mullany