March 6, 2019 Evan Jones Chief Executive Officer OPGEN INC 708 Quince Orchard Road, Suite 205 Gaithersburg, MD 20878 Re: OPGEN INC Registration Statement on Form S-1 Filed March 1, 2019 File No. 333-230036 Dear Mr. Jones: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact David Link at (202) 551-3356 with any questions. Sincerely, Division of Corporation Finance Office of Beverages, Apparel and Mining cc: Mary Mullany